Organoids hold strong potential for applications such as disease modelling, drug discovery and cell therapy. However, their clinical translation requires the ability to generate large numbers of functional cells, a major bottleneck in the field.

In this work, researchers from NEOLIVER partners, including Utrecht University, in collaboration with Scinus Cell Expansion and other institutions, demonstrate an automated approach for the large-scale expansion of human liver organoids.

Using a controlled bioreactor system, organoids were efficiently expanded while maintaining their identity and differentiation potential, a key step towards enabling their clinical use.

The study also highlights the role of advanced bioreactor technologies, such as the Osilaris™ platform, in supporting scalable and reproducible cell manufacturing.